Presentations
Alzheimer’s Treatment and Management
Dr. Anna Burke discusses Adhelm (aducanumab) and other current and emerging treatments for Alzheimer’s disease. Courtesy of Barrow Neurological Institute, January 2022.
Learn about the most current treatments and research for Alzheimer’s disease. Recording courtesy of Barrow Neurological Institute, July 2021.
Anna Burke, MD, director of the Barrow Alzheimer’s and Memory Disorders Program, presents on flourishing in life, love, and intimacy as a dementia care partner. Recording courtesy of Barrow Neurological Institute, April 2021.
Anna Burke, MD, director of the Barrow Alzheimer’s and Memory Disorders Program, presents on flourishing in life, love, and intimacy as a dementia care partner. Recording courtesy of Barrow Neurological Institute, April 2021.
Brain Health and Alzheimer’s Prevention
On November 12, 2020, Banner Health Foundation hosted an online presentation and discussion featuring Eric Reiman, MD, Executive Director of Banner Alzheimer’s Institute (BAI) and Chief Executive Officer of Banner Research and Pierre Tariot, MD, Director of Banner Alzheimer’s Institute (BAI). The program was moderated by Marjorie Bessel, MD, Chief Clinical Officer of Banner Health. During the program, our speakers discussed subjects including the most recent advances in research and strategies to battle Alzheimer’s and dementia at BAI.
Mike Malek-Ahmadi, PhD, discusses how Alzheimer’s disease is defined before symptoms, and how this aides in the development of preventative therapies. Recording courtesy of Banner Health, May 2020.
Jessica Langbaum, PhD, co-directs the Alzheimer’s Prevention Initiative at Banner Alzheimer’s Institute. In her presentation, she discusses the goals of the Alzheimer’s Prevention Initiative Program and how it establishes Alzheimer’s disease trial designs and operations. Recording courtesy of the Wisconsin Alzheimer’s Disease Research Center, April 2020.
Changes in memory occur over the course of typical aging. More severe memory impairment is characteristic of age-associated neurodegenerative disease. Over the past half-century, many myths about the aging brain have been shattered using systems neuroscience approaches, and rodent and nonhuman primate aging models, to define changes in brain and cognition that are normative versus pathological. Barnes will discuss how these data have driven a conceptual shift away from the idea of passive brain deterioration with time, to the view that the brain is capable of remarkable adaptation across the lifespan.
Carol Barnes, PhD is a Regents’ Professor in the Departments of Psychology, Neurology and Neuroscience, the Evelyn F. McKnight Endowed Chair for Learning and Memory in Aging, Director of the Evelyn F. McKnight Brain Institute and Director of the Division of Neural Systems, Memory & Aging at the University of Arizona, Tucson. Dr. Barnes is past-president of the 42,000 member Society for Neuroscience, an elected Fellow of the American Association for the Advancement of Science, and an Elected Foreign Member of the Royal Norwegian Society of Sciences and Letters. Introduction by Sara Burke, PhD – University of Florida, Gainsville Lecture begins at 2:20 Courtesy of and recorded at the 2018 International Conference on Learning and Memory and the University of California, Irvine.
A conversation with David W. Coon, PhD, associate dean of research initiatives, support, and engagement and professor in the Edson College of Nursing and Health Innovation at Arizona State University. Dr. Coon also serves as the director of the Center for Innovation in Healthy & Resilient Aging.
Caregiving
Dr. Anna Burke discusses why behavior changes happen in Alzheimer’s and memory disorders and explains what you can do to help. Recording courtesy of Barrow Neurological Institute, January 2022.
Dr. David Coon is the Associate Dean for Research at the Edson College of Nursing and Health Innovation and runs the Center for Innovation in Healthy & Resilient Aging. Here he talks with Erik Cole about the need for community-engaged support for caregivers and community members facing chronic illnesses, particularly among culturally diverse groups. He describes how, as researchers and practitioners, they “meet people where they are” and co-create support systems and solutions with the impacted community members. Recording courtesy of ASU Watts College, July 2020.
Lecture by Dr. Coon at the first conference “Preparing for the Changing Horizon: LGBT Dementia Care” held at the Milton Marks Conference Center in San Francisco February 20, 2015. Recording courtesy of Stanford Geriatric Education Center.
Overview:
- Key issues in Dementia Care and Caregiving
- Why LGBT Care & Caregiving
- Frameworks
- Call for Action
Conversations With Our Scientists
In an interview with the Multicultural Alzheimer’s Prevention Program at Massachusetts General Hospital, learn about the exciting collaborative research being done by:
- Eric M. Reiman, MD
- Pierre N. Tariot, MD
- Jessica Langbaum, PhD
- Yi Su, PhD
- Kewei Chen, PhD
- Valentina Ghisays, PhD
- Michael Malek-Ahmadi, PhD
- Jeremy Pruzin, MD
Recording courtesy of Banner Alzheimer’s Institute, December 2021. Learn more at www.banneralz.org
Presented at the Arizona Alzheimer’s Consortium Annual Conference, September 9, 2021.
Zaven S. Khachaturian, Ph.D.
President, Prevent Alzheimer’s Disease by 2020, Inc. [PAD 2020]
Editor-in-Chief, Alzheimer’s Dementia: Journal of the Alzheimer’s Association
Senior Science Advisor to the Alzheimer’s Association
Adjunct Professor of Psychiatry and Neuroscience, Johns Hopkins University School of Medicine
Introduction by Eric M. Reiman, MD CEO, Banner Research Executive Director, Arizona Alzheimer’s Consortium
This webinar hosted on May 26, 2021 by the National Alzheimer’s Coordinating Center features 6 speakers, each presenting their chosen topic for 15 minutes with time for discussion. All speakers are associated with the Multi-Institutional Arizona ADRC.
In addition to the online cognitive test, the speakers discuss the managements/sharing of multi-site data, the multivariate approach for structural brain networks, multi-tracer PET data harmonization using machine learning and deep learning, the multiscale networks for high-dimensional omics data, and the fundamentals for Genome-Wide Association Studies (GWAS) and Transcriptome-Wide Association Studies (TWAS).
SPEAKERS
Matthew Huentelman – Translational Genomics Research Institute, Phoenix AZ
Presentation: Lessons from the Crowd: Electronic Recruitment and Study of Cognition in the Digital Age
Summary: Results from our web-based study, MindCrowd (www.mindcrowd.org) will be discussed. We will focus on approaches for electronic-based cohort recruitment and analysis of the resulting big data.
Don Saner – Banner Alzheimer’s Institute, Phoenix AZ
Presentation: Management and Sharing of data from a multi-site ADRC
Summary: The Arizona Alzheimer’s Consortium spans five distinct sites across different institutions. In order to meet the challenge of collecting UDS data, submitting it to NACC and working with sites to remediate data consistency checks, we have deployed the UDS forms (in cooperation with Kansa state) in REDCap and developed several pieces of software that leverage the REDCap API to create a centralized database for NACC submissions, reporting and data sharing.
Gene Alexander – University of Arizona, Tucson AZ
Presentation: Applications of Multivariate Structural Network Covariance for Neuroimaging Biomarkers of Brain Aging and Alzheimer’s Disease Risk
Summary: Investigating regional network patterns may enhance efforts in identifying neuroimaging biomarkers of brain aging and the risk for AD. Multivariate structural network covariance analyses with the scaled subprofile model (SSM) provides regional patterns of MRI gray matter volume related to aging, health, and genetic risk factors, providing relevant novel biomarkers. Applications of SSM to structural MRI in brain aging and AD risk will be discussed, including studies of younger and older adults, in translational research, in non-human primate and small animal models of aging.
Yi Su – Banner Alzheimer’s Institute, Phoenix AZ
Presentation: Tracer harmonization for amyloid PET imaging using statistical and deep learning techniques
Summary: Having multiple PET imaging tracers for amyloid and tau facilitates their wide application but also poses a challenge on how to interpret the imaging results in a unified fashion and to leverage the large datasets that are available. We will discuss our recent efforts developing statistical and machine learning-based techniques to harmonize imaging-based measurements from different tracers.
Benjamin Readhead – ASU-Banner Neurodegenerative Disease Research Center, Tempe, AZ
Presentation: Interrogating the multiscale networks of mitochondrial activity of AD
Summary: The generation of large amounts of high-dimensional molecular data from well characterized clinical cohorts offers new opportunities to engage with AD pathogenesis. This talk will outline emerging work on the dysregulation of mitochondrial networks observed in AD.
Ignazio Piras – Translational Genomics Research Institute, Phoenix, AZ
Presentation: Genome-wide and Transcriptome-wide association studies fundamentals.
Summary: Genome-Wide Association Studies (GWAS) and Transcriptome-Wide Association Studies (TWAS) are widely used approaches applied to detect genetic factors associated with a particular disease/phenotype. Attendants will learn GWAS and TWAS theoretical bases as well as the main bioinformatics tools and workflows. Thank you to our webinar moderators, Dr. Kewei Chen, Dr. Katrina Devick and Dr. Michael Malek Ahmadi
Recording courtesy of the National Alzheimer’s Coordinating Center, May 2021.
Research is the complement to the classroom experience and Edson College of Nursing and Health Innovation undergraduates and graduates alike are able to work with faculty on great challenges ranging in health and health care. David W. Coon, PhD is the associate dean of research initiatives, support, and engagement and professor in the Edson College of Nursing and Health Innovation at Arizona State University. Dr. Coon also serves as the director of the Center for Innovation in Healthy & Resilient Aging. Recording courtesy of ASU Open Door, March 2021.
Being Patient spoke with Jessica Langbaum, PhD, co-director of the Alzheimer’s Prevention Initiative at Banner Alzheimer’s Institute, about how genetics influence people’s risk for developing Alzheimer’s and the implications of genetic testing. Recording courtesy of Live Talk, December 2020.